Efficiency of fenticonazole for the treatment of vaginal candidiasis

Živaljević Biljana, Golubović Ilija, Seratlić Jelena, Nikolić Petar, Simić Dušan, Magdić Ivica, Marić-Krejović Snežana, Marković-Knežević Danijela, Krsmanović Snežana



Uncomplicated vulvovaginal candidiasis appears in 75% women of reproductive age. The most frequent causes are Candida albicans (85-95%) or C. glabrata, and infrequently C. krusei, C. tropicalis, C. parapsilosis, C. pseudotropicalis, etc.


The aim of the study was to investigate efficiency and safety of fenticonazole for vaginal candidiasis treatment.


Therapeutic effect of a single 600 mg fenticonasole vaginal capsule was observed in 417 women, aged 16-67, in five centers in Serbia. In all women, before the treatmentvaginal candidiasis was confirmed by testing of vaginal smear. Based on smear findings and associated symptoms observed on the 7th and 28th day after therapy administration, treatment results were evaluated. On the next day after drug application the patients recorded by using a questionnaire their own feelings on withdrawal symptoms and possible side effects in the period prior to the first control.


Control after seven days showed a statistically significant decrease of symptoms. In 385 women, vaginal smear was found negative to yeast and yeast blastospores. Within the first seven days after treatment 84 women had to repeat therapy due to the persistence of symptoms or positive vaginal smear. After 28 days we recorded full recovery in 392 patients, clinical improvement in eight, no change in 16, and deterioration in one patient only. Side effects were very seldom, mostly in the form of a slight redness of the vulva and vagina, and mild itching during several days.


Our observations confirmed good efficacy and safety of fenticonazole in the treatment of vaginal candidiasis.

Srp Arh Celok Lek. 2012 Jul-Aug;140(7-8):469-74.
Abstract en Pubmed y doiSerbia 

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